Arcus Biosciences

Arcus Biosciences, Inc. is a U.S.-based, clinical-stage biopharmaceutical company dedicated to discovering and commercializing innovative cancer therapies. Its pipeline features several promising drug candidates: Etrumadenant, a dual A2a/A2b adenosine receptor antagonist, is currently in Phase 1b/2 clinical trials. Zimberelimab, an anti-PD-1 antibody, is being evaluated as a monotherapy in Phase 1b studies. Another key asset is Domvanalimab, an anti-TIGIT monoclonal antibody, undergoing Phase 2 development for first-line metastatic non-small cell lung cancer when administered with Zimberelimab. The company is also developing Quemliclustat, a small-molecule CD73 inhibitor, in Phase 1/1b studies for the initial treatment of metastatic pancreatic cancer. AB521, an oral small molecule HIF-2a inhibitor, is in Phase 1 trials for patients with von Hippel-Lindau disease. Arcus actively collaborates with other entities to advance its programs. It has a clinical development partnership with Strata Oncology, Inc. to assess Zimberelimab. Furthermore, a significant collaboration with AstraZeneca and BVF Partners L.P. is underway for a registrational Phase 3 clinical trial, testing Domvanalimab (an experimental anti-TIGIT antibody) alongside Imfinzi (durvalumab) in patients with unresectable Stage III non-small cell lung cancer. Additionally, Arcus holds licensing agreements with Taiho Pharmaceutical Co., Ltd, Abmuno Therapeutics LLC, and WuXi Biologics for the development of an anti-CD39 antibody targeting various cancers. Incorporated in 2015, the company's corporate headquarters are located in Hayward, California.